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Description
Students are shown how to predict the solubilities, structure-activity relationships, basic synthesis routes for selected structures, metabolism and pharmacological activity/potency of drug classes and individual members of classes based on the contribution of their functional groups to their structures. In particular antidiabetics, anticonvulsants, H1 and H2 antagonists, analgetics, nonsteroidal anti-inflammatory drugs, hormones, antibiotics, antiviral agents, and antineoplastic agents are covered.
This course incorporates concepts essential to the drug design & development process for the above-mentioned drug classes:
- Preparing students for communication with other stakeholders in drug development by identifying current drug targets and applying mechanism of drug action.
- Solidifying concepts in drug-target interactions through pharmacophore design and applications of rational drug design to optimize a structure for clinical testing.
- Increasing the clinical and marketing success of a drug structure by optimizing pharmacokinetic and pharmacodynamic properties in early drug development.
- Facilitating an in-depth understanding of medical and clinical concepts important to cross talk and engagement with other stakeholders during the development stages.
Course Goal
In recent years an increasing demand for antibiotic and antiviral drugs, as well as new approaches to chemotherapy treatment have been noted. In order to facilitate the development of new drugs in these and other areas, a solid understanding of current drug targets, their mechanism of action, and pharmacophore structures is essential. At the completion of the course, students will be able to effectively communicate with medical, legal, and management professionals about the drug classes covered in this class to drive the drug development process.
Prerequisites
PHA 6432 Fundamentals of Pharmaceutical Chemistry.
Topics
| Module | Topic |
|---|---|
| Module 1 | Anti-diabetes Drugs |
| Module 2 | Anti-epileptic Drugs |
| Module 3 | Antihistamines |
| Module 4 | Narcotic Analgetics |
| Module 5 | Nonsteroidal Anti-Inflammatory Drugs |
| Module 6 | Sex Hormones & Steroids |
| Module 7 | Antibiotic Agents – Sulfonamides & Quinolones |
| Module 8 | Antibiotic Agents – Penicillins |
| Module 9 | Antibiotic Agents – Cephalosporins, Carbapenems, and Monobactams |
| Module 10 | Antibiotic Agents – Tetracyclines & Macrolides |
| Module 11 | Antibiotic Agents – Aminoglycosides & Other Antibiotics |
| Module 12 | Antiviral Agents |
| Module 13 | Chemotherapeutic Agents |
Course Structure
Group discussion forums, online chat sessions, asynchronous mini-lectures, online timed quizzes, interactive animations, and individual e-mail contact between student and instructor. Students will be required to submit written essay assignments as well as complete timed quizzes. The instructor will also be frequently available for one-on-one virtual office hours.
Recommended Materials
There is no single recommended text for this course. Helpful textbooks include:
- Goodman & Gilman’s The Pharmacological Basis of Therapeutics
Author: Laurence L. Brunton, Bjorn Christian Knollmann
Publisher: McGraw-Hill Professional; 14th edition (2022)
ISBN: 978-1264258079 - Foye’s Principles of Medicinal Chemistry
Author: Thomas L. Lemke, David A. Williams, Victoria F. Roche, S. William Zito
Publisher: Wolters Kluwer, Lippincott Williams & Wilkins; 8th edition (2019)
ISBN: 978-1496385024
Library Access
UF online graduate students enjoy the same library privileges as on-campus students. Visit the University of Florida Libraries to find books, journals and more.