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Principles of Drug Action & Development II

PHA 6935 Principles of Drug Action & Development II

Credits: 3


Students are shown how to predict the solubilities, structure-activity relationships, basic synthesis routes for selected structures, metabolism and pharmacological activity/potency of drug classes and individual members of classes based on the contribution of their functional groups to their structures. In particular antidiabetics, anticonvulsants, H1 and H2 antagonists, analgetics, nonsteroidal anti-inflammatory drugs, hormones, antibiotics, antiviral agents, and antineoplastic agents are covered.

This course incorporates concepts essential to the drug design & development process for the above-mentioned drug classes:

  • Preparing students for communication with other stakeholders in drug development by identifying current drug targets and applying mechanism of drug action.
  • Solidifying concepts in drug-target interactions through pharmacophore design and applications of rational drug design to optimize a structure for clinical testing.
  • Increasing the clinical and marketing success of a drug structure by optimizing pharmacokinetic and pharmacodynamic properties in early drug development.
  • Facilitating an in-depth understanding of medical and clinical concepts important to cross talk and engagement with other stakeholders during the development stages.

Course Goal

In recent years an increasing demand for antibiotic and antiviral drugs, as well as new approaches to chemotherapy treatment have been noted. In order to facilitate the development of new drugs in these and other areas, a solid understanding of current drug targets, their mechanism of action, and pharmacophore structures is essential. At the completion of the course, students will be able to effectively communicate with medical, legal, and management professionals about the drug classes covered in this class to drive the drug development process.


PHA 6432 Fundamentals of Pharmaceutical Chemistry


Module Topic
Module 1 Anti-diabetes Drugs
Module 2 Anti-epileptic Drugs
Module 3 Antihistamines
Module 4 Narcotic Analgetics
Module 5 Nonsteroidal Anti-Inflammatory Drugs
Module 6 Sex Hormones & Steroids
Module 7 Antibiotic Agents – Sulfonamides & Quinolones
Module 8 Antibiotic Agents – Penicillins
Module 9 Antibiotic Agents – Cephalosporins, Carbapenems, and Monobactams
Module 10 Antibiotic Agents – Tetracyclines & Macrolides
Module 11 Antibiotic Agents – Aminoglycosides & Other Antibiotics
Module 12 Antiviral Agents
Module 13 Chemotherapeutic Agents

Course Structure

Group discussion forums, online chat sessions, asynchronous mini-lectures, online timed quizzes, interactive animations, and individual e-mail contact between student and instructor. Students will be required to submit written essay assignments as well as complete timed quizzes. The instructor will also be frequently available for one-on-one virtual office hours.

Recommended Materials

There is no single recommended text for this course. Helpful textbooks include:

  • Goodman & Gilman’s The Pharmacological Basis of Therapeutics
    Author: Laurence L. Brunton, Bruce A. Chabner, Bjorn Christian Knollmann
    Publisher: McGraw-Hill Professional; 12th edition (2010)
    ISBN: 978-0071624428
  • Foye’s Principles of Medicinal Chemistry
    Author: Thomas L. Lemke, David A. Williams, Victoria F. Roche, S. William Zito
    Publisher: Wolters Kluwer, Lippincott Williams & Wilkins; 6th edition (2008)
    ISBN: 9780781768795

Library Access

Distance Education and UF Online Students enjoy the same library privileges as on-campus students. To utilize the University of Florida Library System, click here!

At a Glance