Students are shown how to predict the solubilities, structure-activity relationships, basic synthesis routes for selected structures, metabolism and pharmacological activity/potency of drug classes and individual members of classes based on the contribution of their functional groups to their structures. In particular, anticoagulants, ACE inhibitors, glucocorticoid steroids, nitrate esters, adrenergics, cholinergics, diuretics, anesthetics, antihyperlipidemics, muscle relaxants, anxiolytics, antidepressants, sedative hypnotics and vitamins are covered.
This course incorporates concepts essential to the drug design & development process for the above-mentioned drug classes:
- Preparing students for communication with other stakeholders in drug development by identifying current drug targets and applying mechanism of drug action.
- Solidifying concepts in drug-target interactions through pharmacophore design and applications of rational drug design to optimize a structure for clinical testing.
- Increasing the clinical and marketing success of a drug structure by optimizing pharmacokinetic and pharmacodynamic properties in early drug development.
- Facilitating an in-depth understanding of medical and clinical concepts important to cross talk and engagement with other stakeholders during the development stages.
The high volume of prescription drugs on the market indicates a need for an understanding of essential concepts related to the mechanism of action and structure-activity relationship of currently available drugs as well as projection of future targets for drug development. An in-depth understanding of blockbuster drug classes such as the statins, angiotensin-converting enzyme (ACE) inhibitors, and selective serotonin reuptake inhibitors (SSRIs) including future directions for structural modifications and new applications is at the core of Pharmaceutical Chemistry 1. Students will be able to comprehensively describe drug classes discussed in this course which will enable them to effectively communicate with other scientists, medical professionals, and management during the drug development process.
Fundamentals of Pharmaceutical Chemistry
|Module 1||General principles|
|Module 4||Cardiovascular drugs – Vasodilators|
|Module 5||Cardiovascular drugs – Antihyperlipidemics|
|Module 6||Glucocorticoid steroids|
|Module 8||General and local anesthetics|
|Module 9||Central nervous system – Adrenergic agents|
|Module 10||Central nervous system – Cholinergic agents, Anticholinergics, Skeletal muscle relaxants, Antialzheimer agents|
|Module 11||Central nervous system – Antipsychotics and Antiparkinson agents|
|Module 12||Central nervous system – Antidepressants, serotonin drugs and anxiolytic agents|
Group discussion forums, online chat sessions, asynchronous mini-lectures, online timed quizzes, interactive animations, and individual e-mail contact between student and instructor. Students will be required to submit written essay assignments as well as complete timed quizzes. The instructor will also be frequently available for one-on-one virtual office hours.
There is no single recommended text for this course. Helpful textbooks include:
- Goodman & Gilman’s The Pharmacological Basis of Therapeutics
Author: Laurence L. Brunton, Bruce A. Chabner, Bjorn Christian Knollmann
Publisher: McGraw-Hill Professional; 12th edition (2010)
- Foye’s Principles of Medicinal Chemistry
Author: Thomas L. Lemke, David A. Williams, Victoria F. Roche, S. William Zito
Publisher: Wolters Kluwer, Lippincott Williams & Wilkins; 6th edition (2008)
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