This course has been developed to introduce students to the procedures and processes associated with the production, isolation, characterization and use of medicinal drugs of plant origin.
The College of Pharmacy at the University of Florida offers a course in herbal and dietary supplements to healthcare professionals interested in advancing their knowledge in this growing field.
This course focuses on the characterization and the structural proof of drug compounds routinely encountered in Forensic and Pharmaceutical laboratories. Each module, accompanied by specific aims, will be supplemented with figures, animations, and links to appropriate web sites that will provide the materials necessary for course completion.
This course provides a strong conceptual foundation of enzymology and mechanisms of drug biotransformation pathways. As a foundation for learning, we will provide examples of drugs and other xenobiotics that exhibit toxicity related to biotransformation. Students are expected to use information presented in each module to develop and complete given assignments.
This is a foundation course whose aims are to provide an introduction to the principles of Medicinal chemistry, including an understanding of drug structure-activity relationships, prediction of the physico-chemical properties of a drug, basic knowledge of the major pathways of drug metabolism, and factors that can contribute to drug-drug interactions.
Students are shown how to predict the solubilities, structure-activity relationships, basic synthesis routes for selected structures, metabolism and pharmacological activity/potency of drug classes and individual members of classes based on the contribution of their functional groups to their structures.
This course focuses on the methods used in the synthesis of organic compounds with particular attention to medicinal products and illicit substances. Students are expected to utilize information presented in each module to develop and complete their module assignments. Other activities will include online discussions of course topics and current issues that relate to the synthesis of medicinal products and illicit substances.
This course will introduce students to the chemical structure of DNA and RNA; the synthetic processes for DNA and RNA synthesis; biochemical reactions and pathways for nucleotide synthesis; DNA replication, transcription and translation; covalent and reversible interactions of nucleic acids with small molecules and proteins and an overview of techniques for the analysis of nucleic acids.
While early-stage drug design and development principles were discussed in PHA6444 Pharmaceutical Chemistry 1, this course will focus on additional in vivo testing and necessary data collection and condensation to meet the requirements for submission of an investigational new drug application (IND) to the US FDA. This is a critical step for a drug development company as it narrows down potential lead structures and seeks to gather essential information to ensure that the drug candidate can be approved for First-in-Human trials.
This book based course will introduce students to the principles of anabolic and catabolic pathways and cellular energy efficiency. The course also provides an understanding of the biological, physical and chemical processes for each reaction pathway.
This course introduces the use of spectroscopic methods and tools (IR, NMR, MS, UV) for the accurate determination of molecular structure. This skill is essential for chemists in many areas, such as medicinal chemistry, process chemistry, natural products chemistry, forensic chemistry, and many other sub-specialties of analytical chemistry. This course will prepare students with an up-to-date presentation of the tools used for the advanced analysis and structure elucidation of organic molecules.
This course provides a strong conceptual foundation of the diverse molecular and cellular processes involved in cancer development and the multiple strategies to fight the disease. The focus of the course will be on colon cancer development. Students will learn to analyze data from high throughput screenings of colon cancer patients, and acquire a good understanding how to use this information to plan and carry out a project in applied research and product development in the field of anti-cancer drug development.
Participants in this course will explore the rational formulation and manufacture of dosage forms for all major routes of drug administration. We begin with an overview of the drug development process, followed by a review of the major concepts of biopharmaceutics and pharmaceutical preformulation. With an understanding of these concepts, we will methodically explore how stable and effective dosage forms are developed and manufactured with respect to their intended routes of administration. While the focus will be on small molecule drugs, we will conclude with an overview of the formulation and administration of therapeutic proteins.
Students are shown how to predict the solubilities, structure-activity relationships, basic synthesis routes for selected structures, metabolism and pharmacological activity/potency of drug classes and individual members of classes based on the contribution of their functional groups to their structures. In particular, anticoagulants, ACE inhibitors, glucocorticoid steroids, nitrate esters, adrenergics, cholinergics, diuretics, anesthetics, antihyperlipidemics, muscle relaxants, anxiolytics, antidepressants, sedative hypnotics and vitamins are covered.
Students are shown how to predict the solubilities, structure-activity relationships, basic synthesis routes for selected structures, metabolism and pharmacological activity/potency of drug classes and individual members of classes based on the contribution of their functional groups to their structures. In particular antidiabetics, anticonvulsants, H1 and H2 antagonists, analgetics, nonsteroidal anti-inflammatory drugs, hormones, antibiotics, antiviral agents, and antineoplastic agents are covered.
This one-credit course is a two-day orientation and final comprehensive examination. It will include an online orientation via BigBlueButton, the final written comprehensive examination online taken via ProctorU, and an oral examination for completion of the MS degree requirements. Students should register for this course in their final semester of their MS degree. The University of Florida requires that you are registered for the following number of credits during the term you are graduating: Summer term: 2 credit hours; Fall/Spring term: 3 credit hours. Because the Special Topics course is only 1 credit, you will need to be sure you meet the credit requirement as noted above.
This introductory course covers key concepts related to the cellular actions, therapeutic uses, side effects and toxic actions of major drug classes used in humans and non-human species. Students will learn key concepts that are important to understanding drug actions, including principles of pharmacokinetics (e.g., absorption, distribution, metabolism and excretion of drugs) as well as the physiological and cellular basis for a host of diverse drug actions. Major drug classes covered in this course include (among others), agents that act upon the nervous system (both central and peripheral), skeletal muscle, the heart, the cardiovascular system and kidneys, as well as agents used to combat microbial diseases.
This course teaches the key components of QA/QC and will help students to understand the need to produce sound scientific data using appropriate standards and controls, written procedures and method validation no matter what field they are employed in. This course will offer a generic description of what is required in the formation of a quality system in any laboratory.